Population studies indicate that high intakes of calcium from the diet are linked with low BP, whereas clinical trials using calcium supplements to lower BP have been less compelling. 58, 59 A high dietary intake of calcium has been associated with both a decrease in BP and the risk of developing hypertension. 60, 61 Ascherio and coworkers 23 also demonstrated in more than 30,000 normotensive male health professionals aged 40 to 75 years that men consuming <250 mg/d of calcium had a 50% greater chance of developing hypertension than those who consumed ?400 mg/d. In a prospective cohort of 28,886 US women older than 45 years, 62 dietary intake of calcium was inversely associated with risk of hypertension; however, no change in BP was observed with calcium supplementation. Sacks and colleagues 52 reported no significant effect on BP in 94 patients randomly assigned to receive placebo or combination therapy with either calcium and magnesium or calcium and potassium for 6 months.
Calcium supplements supplements wasn’t demonstrated to stop an increase in BP otherwise blood circulation pressure. Regarding Demo out of Hypertension Prevention (TOHP), thirty five 445 normotensive people were randomly allotted to found sometimes placebo or step one grams away from calcium each day to have 6 months. You will find no difference between BP amongst the organizations. At the same time, TOHP-step one checked-out the fresh independent outcomes of micronutrients into the BP into the hypertensive clients that have an effective diastolic BP away from 80 to 89 mm Hg. Develops in the weight loss calcium and magnesium got just a little perception to your BP, whereas limitation out-of sodium intake and you can losing weight led to significant decreases from inside the BP. thirty five
One or two meta-analyses of randomized trials advertised a small reduction in BP that have calcium supplements supplementation, but none demanded calcium supplementation. 63, 64 Various other meta-investigation of the results of calcium supplements on BP claimed a good reduction in systolic BP and you can diastolic BP from 2.step 1 mm Hg and you may step 1.1 mm Hg, respectively, when you look at the hypertensive people. 65 Within this meta-investigation, calcium-who has delicacies had been found to be better in lowering BP than just was calcium supplementation. A newer meta-analysis out of 13 RCTs that have ranging from 8 and you can fifteen weeks’ realize-up indicated that members researching calcium supplements supplements had a statistically tall loss in systolic BP yet not diastolic BP in comparison with a running group. twenty-eight Because of the heterogeneity ranging from examples, the evidence linked calcium supplementation and you can BP reduction are weakened. Like with most other training with various nutrients and you will BP, many studies have been brief in years and then have got pair users. Far more double-blind placebo-controlled trials away from offered years and higher quality are necessary to even more accurately assess the aftereffect of calcium supplements supplementation on the BP and you can cardio effects.
In two education, people getting >800 mg/d regarding calcium supplements weighed against eight hundred mg/d reached a beneficial 23% reduction in threat of development blood pressure levels
Resnick 66 possess offered dos you can systems for the some responses so you’re able to calcium supplements, talked about in more detail lower than. A decrease in calcium supplements about eating plan could potentially cause calcium depletion from most of the membrane layer shops websites, ultimately causing faster balance of the vascular simple strength cellphone membrane layer. 67 Whenever within optimum density, calcium balances vascular mobile walls, suppress its own entry towards the cells, and you can decrease vasoconstriction. 42 Calcium supplements really works in combination with almost every other ions such as salt, potassium, and you may magnesium die besten kostenlosen Dating-Seiten für Erwachsene to provide an ionic balance on the vascular membrane, vasodilatation, and you may resulting smaller BP.
Ideas for Calcium supplements Intake
There can be presently zero research to help you recommend the effective use of calcium supplementation having aerobic defense besides an acceptable slimming down consumption. 21 To own normotensive people, calcium supplementation above the required daily dietary consumption is not recommended as an easy way from preventing an increase in BP. As well, calcium supplements over the demanded every day diet intake is not required as a solution to blood pressure level.
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